Isabelle Plo Selected Research

Calreticulin

12/2021	Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.
12/2021	CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag.
7/2021	Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms.
1/2020	Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development.
1/2020	Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms.
1/2020	Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN.
1/2020	Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms.
1/2020	Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis.
1/2019	Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants.
1/2019	Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice.

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Isabelle Plo Research Topics

Disease

26	Neoplasms (Cancer) 12/2021 - 05/2009
12	Primary Myelofibrosis (Myelosclerosis) 07/2021 - 01/2016
12	Essential Thrombocythemia 07/2021 - 02/2014
9	Polycythemia Vera 01/2022 - 01/2016
5	Thrombocytosis (Thrombocythemia) 01/2017 - 02/2014
3	Thrombocytopenia (Thrombopenia) 12/2021 - 01/2017
3	Leukemia 01/2021 - 08/2002
2	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 09/2019
2	Hypersensitivity (Allergy) 01/2018 - 08/2009
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 04/2017 - 05/2009
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 06/2016 - 05/2009
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2016 - 04/2013
1	Dehydration (Water Stress) 12/2021
1	Thrombosis (Thrombus) 12/2021
1	Congenital amegakaryocytic thrombocytopenia 12/2021
1	Acute Promyelocytic Leukemia 01/2021
1	Hyperplasia 01/2020
1	Splenomegaly 01/2020
1	Fibrosis (Cirrhosis) 12/2018
1	Disease Progression 12/2018
1	Idiopathic Pulmonary Fibrosis 12/2018
1	Polycythemia (Erythrocytosis) 01/2018
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2018
1	primary familial and congenital Polycythemia 01/2018
1	Inflammation (Inflammations) 01/2018
1	Immune System Diseases (Immune Disorders) 01/2018
1	Neutropenia 01/2018
1	Exocrine Pancreatic Insufficiency 01/2018
1	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 01/2018
1	Rheumatoid Arthritis 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2017
1	Glioma (Gliomas) 01/2017
1	Tetraploidy 12/2016
1	Polyploidy 12/2016
1	Ataxia Telangiectasia (Louis Bar Syndrome) 08/2009
1	Genomic Instability 11/2008

Drug/Important Bio-Agent (IBA)

14	CalreticulinIBA 12/2021 - 09/2014
7	Thrombopoietin (c-mpl Ligand)IBA 12/2021 - 02/2014
5	Thrombopoietin ReceptorsIBA 12/2021 - 01/2016
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2016
3	Janus Kinase 2IBA 12/2021 - 05/2009
2	CalciumIBA 12/2021 - 01/2020
2	Pharmaceutical PreparationsIBA 07/2021 - 08/2002
2	InterferonsIBA 01/2021 - 01/2020
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 11/2017
2	Biological ProductsIBA 01/2020 - 06/2016
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2018 - 08/2009
2	4,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA 01/2017 - 12/2016
2	Phosphotransferases (Kinase)IBA 02/2014 - 08/2009
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/2021
1	Arsenic Trioxide (Trisenox)FDA Link 01/2021
1	ArsenicIBA 01/2021
1	Reticulin (Reticular Fiber)IBA 01/2020
1	Recombinant ProteinsIBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Dihydrotachysterol (AT 10)IBA 12/2019
1	A-Form DNA (A-DNA)IBA 09/2019
1	HSP27 Heat-Shock ProteinsIBA 12/2018
1	apatorsenIBA 12/2018
1	Antisense OligonucleotidesIBA 12/2018
1	Peptides (Polypeptides)IBA 01/2018
1	EnzymesIBA 01/2018
1	tofacitinibIBA 01/2018
1	Janus Kinase InhibitorsIBA 01/2018
1	ruxolitinibIBA 01/2018
1	Methotrexate (Mexate)FDA LinkGeneric 01/2018
1	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2018
1	Erythropoietin FDA Link 01/2018
1	Erythropoietin Receptors (Erythropoietin Receptor)IBA 01/2018
1	DiamondIBA 01/2018
1	Amino Acids FDA Link 01/2018
1	Histone Deacetylases (Histone Deacetylase)IBA 11/2017
1	Ribosomal Proteins (Ribosomal Protein)IBA 04/2017
1	gamma-Aminobutyric Acid (GABA)IBA 01/2017
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2017
1	ProteomeIBA 01/2017
1	Etoposide (VP 16)FDA LinkGeneric 12/2016
1	GTP Phosphohydrolases (GTPases)IBA 11/2016
1	STAT5 Transcription FactorIBA 03/2016
1	Autophagy-Related ProteinsIBA 03/2016
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2016
1	CytokinesIBA 01/2016
1	Tyrosine Kinase InhibitorsIBA 04/2013
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 03/2013
1	DNA (Deoxyribonucleic Acid)IBA 09/2011
1	5-Methylcytosine (5 Methylcytosine)IBA 09/2011
1	5-hydroxymethylcytosineIBA 09/2011
1	Granulocyte Colony-Stimulating Factor Receptors (G-CSF Receptor)IBA 08/2009
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2008
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 08/2002
1	PKC-3 proteinIBA 08/2002
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 08/2002
1	CeramidesIBA 08/2002

Therapy/Procedure

4	Therapeutics 01/2021 - 09/2014
2	Transplantation 01/2022 - 05/2009
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2021
1	Immunotherapy 01/2020
1	Drug Therapy (Chemotherapy) 09/2019